Long-term Exposure to Ambient PM2.5 and the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD): A Population-Based Cohort Study

Maria Santos

doi:10.71222/pnsqe109

Authors

Maria Santos Department of Environmental Science, Pangasinan State University, Lingayen, Philippines Author

DOI:

https://doi.org/10.71222/pnsqe109

Keywords:

PM2.5, NAFLD, Environmental Health, Cohort Study, Chronic Disease

Abstract

This research article investigate the relationship between long-term exposure to ambient PM2.5 and the progression of Non-Alcoholic Fatty Liver Disease (NAFLD) in a population-based cohort. Utilise molding and a robust dataset, the survey appraise the impact of particulate matter on liver health over time. The findings patently unveil significant association between PM2.5 exposure and accelerated NAFLD progression, accent the demand for targeted health interventions. As intermediary of this relationship, the study farther search possible mechanism, include oxidative accent and inflammation. This work render critical insights into environmental health risks and their implications for disease management.

References

1. F. R. Li et al., "Long-term exposure to air pollution and incident non-alcoholic fatty liver disease and cirrhosis: A cohort study," Liver Int., vol. 43, no. 2, pp. 299-307, 2023.

2. S. H. Cho et al., "Association between long-term exposure to ambient air pollution and an increased risk of steatotic liver disease," Sci. Rep., vol. 15, no. 1, pp. 21922, 2025.

3. X. Kong et al., "Associations of ambient air pollution and lifestyle with the risk of NAFLD: A population-based cohort study," BMC Public Health, vol. 24, no. 1, pp. 2354, 2024.

4. X. Zhang et al., "Combined effect of biological age and fine particulate matter pollution with risk of nonalcoholic fatty liver disease in the UK Biobank: A prospective cohort study," Am. J. Epidemiol., vol. 195, no. 4, pp. 912-918, 2026.

5. S. Sun et al., "Long-term exposure to fine particulate matter and non-alcoholic fatty liver disease: A prospective cohort study," Gut, vol. 71, no. 2, pp. 443-445, 2022.

6. Y. Zhao et al., "Exposure to PM2.5 and its constituents is associated with metabolic dysfunction-associated fatty liver disease: A cohort study in Northwest of China," Environ. Geochem. Health, vol. 46, no. 9, pp. 304, 2024.

7. B. Guo et al., "Long-term exposure to ambient PM2.5 and its constituents is associated with MAFLD," JHEP Rep., vol. 5, no. 12, pp. 100912, 2023.

8. P. Deng et al., "Association of long-term ambient fine particulate matter (PM2.5) and incident non-alcoholic fatty liver disease in Chinese adults," Environ. Pollut., vol. 329, pp. 121666, 2023.

9. C. Matthiessen et al., "Long-term exposure to air pollution and prevalent nonalcoholic fatty liver disease," Environ. Epidemiol., vol. 7, no. 5, pp. e268, 2023.

10. Y. Xing et al., "Associations between exposure to ambient particulate matter and advanced liver fibrosis in Chinese MAFLD patients," J. Hazard. Mater., vol. 460, pp. 132501, 2023.

11. Y. C. Chen, S. C. Pan, W. S. Chin, C. D. Wu, and Y. L. Guo, "Long-term exposure to ambient air pollution and the incidence of nonalcoholic fatty liver disease: A cohort study," Int. J. Epidemiol., vol. 54, no. 4, pp. dyaf101, 2025.

12. Z. Zhu, W. Zhu, H. Zhou, and Z. Wu, "Association between exposure to air pollutants and NAFLD/MAFLD: A meta-analysis," BMC Public Health, vol. 25, no. 1, pp. 2672, 2025.