Sustainable Urease Inhibition in Agriculture: Advances in Chemical Stabilizers and Copper Coordination Polymers

Yangyang Zhai; Grant E. Thornton

doi:10.71222/c6c2d981

Authors

Yangyang Zhai University of Massachusetts Boston, Boston, USA Author
Grant E. Thornton University of Massachusetts Boston, Boston, USA Author

DOI:

https://doi.org/10.71222/c6c2d981

Keywords:

urease inhibition, nitrogen use efficiency, chemical stabilizers, copper coordination polymers, second auxiliary ligands

Abstract

Urease-mediated hydrolysis of urea fertilizer leads to significant nitrogen losses through ammonia volatilization and environmental pollution, posing challenges to sustainable agriculture. Effective urease inhibition is crucial for enhancing nitrogen use efficiency (NUE) and minimizing ecological impact. This review examines two promising strategies for urease inhibition: traditional chemical stabilizers and emerging copper coordination polymers (Cu-CPs) engineered via second auxiliary ligands. Chemical stabilizers such as NBPT have demonstrated rapid urease inhibition but suffer from limitations including short duration and environmental instability. In contrast, Cu-CPs offer tunable structural features and sustained release properties, enabling prolonged urease inhibition alongside multifunctional benefits such as antimicrobial activity. Comparative analyses highlight potential synergies between these approaches, including hybrid formulations that combine immediate and long-lasting effects. Key challenges such as environmental safety, field-level validation, and mechanistic understanding are discussed. Finally, the review advocates for a systems-based interdisciplinary approach to develop eco-friendly, cost-effective urease inhibitors that support sustainable nitrogen management and global food security.

References

1. W.-L. Duan, C. Ma, J. Luan, F. Ding, F. Yan, and L. Zhang, "Fabrication of multinuclear copper cluster-based coordination polymers as urease inhibitors," Dalton Trans., vol. 53, no. 3, pp. 1336–1345, 2024, doi: 10.1039/D3DT03459C.

2. G. Xie, W. Guo, Z. Fang, Z. Duan, X. Lang, D. Liu, G. Mei, Y. Zhai, X. Sun, and X. Lu, "Dual-metal sites drive tandem electro-catalytic CO₂ to C₂⁺ products," Angew. Chem., vol. 136, no. 47, p. e202412568, 2024, doi: 10.1002/ange.202412568.

3. F. Ding, C. Ma, W. L. Duan, and J. Luan, "Second auxiliary ligand induced two coppor-based coordination polymers and urease inhibition activity," J. Solid State Chem., vol. 331, p. 124537, 2024, doi: 10.1016/j.jssc.2023.124537.

4. W.-L. Duan, C. Ma, J. Luan, F. Ding, F. Yan, and L. Zhang, "Fabrication of Substituent-Regulated Two-Dimensional Cop-per-Based Coordination Polymers as Urease Inhibitors," Cryst. Growth Des., vol. 24, no. 5, pp. 2024–2032, 2024, doi: 10.1021/acs.cgd.3c01330.

5. F. Ding, N. Su, C. Ma, B. Li, W. L. Duan, and J. Luan, "Fabrication of two novel two-dimensional copper-based coordination polymers regulated by the 'V'-shaped second auxiliary ligands as high-efficiency urease inhibitors," Inorg. Chem. Commun., vol. 170, p. 113319, 2024, doi: 10.1016/j.inoche.2024.113319.

6. B. He, Q. Wang, X. Zhang, D. Shi, Z. You, and D. Zhang, "Syntheses, X-ray crystal structures and urease inhibition of copper (II) and nickel (II) complexes derived from 5-bromo-2-(((2-(pyrrolidin-1-yl) ethyl) imino) methyl) phenol," Inorg. Chim. Acta, vol. 558, p. 121738, 2023, doi: 10.1016/j.ica.2023.121738.

7. S. Li, L. Xiao, L. Xiao, H. Tan, and Y. Zhang, "Coordination polymer nanoprobe integrated carbon dot and phenol red for turn-on fluorescence detection of urease activity," Microchim. Acta, vol. 190, no. 2, p. 79, 2023, doi: 10.1007/s00604-023-05644-y.

8. S. Han and Y. Wang, "Synthesis, Characterization and Crystal Structures of Schiff Base Copper Complexes with Urease Inhib-itory Activity," Acta Chim. Slov., vol. 68, no. 4, pp. 891–897, 2021, doi: 10.17344/acsi.2021.6965.

9. J. Valentova, L. Lintnerova, B. Slavikova, P. Baran, and M. Urban, "Chiral ligand induced geometrical type of isomerism in Schiff-base Copper (II) complexes with urease inhibitory activities," Inorg. Chim. Acta, vol. 558, p. 121707, 2023, doi: 10.1016/j.ica.2023.121707.

10. J. Jiang, P. Liang, A. Li, Q. Xue, H. Yu, and Z. You, "Synthesis, Crystal Structures and Urease Inhibition of Zinc (II) and Copper (II) Complexes Derived from 2-Amino-N′-(1-(Pyridin-2-yl) Ethylidene) Benzohydrazide," J. Struct. Chem., vol. 64, no. 3, pp. 365–376, 2023, doi: 10.1134/S0022476623030034.

11. F. Ding, C. Y. Hung, J. K. Whalen, L. Wang, Z. Wei, and L. Zhang et al., "Potential of chemical stabilizers to prolong urease inhibition in the soil–plant system," J. Plant Nutr. Soil Sci., vol. 185, no. 3, pp. 384–390, 2022, doi: 10.1002/jpln.202100314.

12. W.-L. Duan, C. Ma, J. Luan, F. Ding, F. Yan, and L. Zhang, "Fabrication of metal–organic salts with heterogeneous confor-mations of a ligand as dual-functional urease and nitrification inhibitors," Dalton Trans., vol. 52, no. 40, pp. 14329–14337, 2023, doi: 10.1039/D3DT01375H.